Hoy día 19 de diciembre de 2018, voy a comer con dos excelentes personas dedicadas a la investigación de patologías neurodegenerativas, una mujer y un hombre, ambos profesores de Biotecnología del Grado de Medicina de la Universidad Jaime I de Castellón. Ella, Ana, está peleando con la enfermedad de Alzheimer, entre otras cosas, y él, Vicente, desarrolla investigación básica sobre el ictus y otros procesos neurodegenerativos, también entre otras areas de interés. Ana está trabajando para obtener una terapia génica y él investigando la neurogénesis y las terapias regenerativas.
Abajo les refiero lo que Pubmed recoge de sus publicaciones.
Ana María Sanchez Perez
Vicente Herranz Pérez
Le ruego evalúe la presente entrada asignando un valor de 1 a 5, de peor a mejor valorada, usando la
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Ana María Sanchez Perez
| Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons. |
Albert-Gasco H, Sanchez-Sarasua S, Ma S, García-Díaz C, Gundlach AL, Sanchez-Perez AM, Olucha-Bordonau FE.
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| Brain Struct Funct. 2018 Oct 28. doi: 10.1007/s00429-018-1763-5. [Epub ahead of print] |
| Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in 'social brain' circuits of rats. |
García-Díaz C, Sánchez-Catalán MJ, Castro-Salazar E, García-Avilés A, Albert-Gascó H, Sánchez-Sarasúa de la Bárcena S, Sánchez-Pérez AM, Gundlach AL, Olucha-Bordonau FE.
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| Behav Brain Res. 2019 Jan 1;356:332-347. doi: 10.1016/j.bbr.2018.08.035. Epub 2018 Sep 5. |
| Silica-gelatin hybrid sol-gel coatings: A proteomic study with biocompatibility implications. |
Araújo-Gomes N, Romero-Gavilán F, Lara-Sáez I, Elortza F, Azkargorta M, Iloro I, Martínez-Ibañez M, Martín de Llano JJ, Gurruchaga M, Goñi I, Suay J, Sánchez-Pérez AM.
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| J Tissue Eng Regen Med. 2018 Jul;12(7):1769-1779. doi: 10.1002/term.2708. Epub 2018 Jun 12. |
| Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling. |
Olucha-Bordonau FE, Albert-Gascó H, Ros-Bernal F, Rytova V, Ong-Pålsson EKE, Ma S, Sánchez-Pérez AM, Gundlach AL.
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| CNS Neurosci Ther. 2018 Aug;24(8):694-702. doi: 10.1111/cns.12862. Epub 2018 May 2. Review. |
 Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression. |
Ribes-Navarro A, Atef M, Sánchez-Sarasúa S, Beltrán-Bretones MT, Olucha-Bordonau F, Sánchez-Pérez AM.
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| Mol Neurobiol. 2018 May 2. doi: 10.1007/s12035-018-1091-z. [Epub ahead of print] |
| Osseointegration mechanisms: a proteomic approach. |
Araújo-Gomes N, Romero-Gavilán F, García-Arnáez I, Martínez-Ramos C, Sánchez-Pérez AM, Azkargorta M, Elortza F, de Llano JJM, Gurruchaga M, Goñi I, Suay J.
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| J Biol Inorg Chem. 2018 May;23(3):459-470. doi: 10.1007/s00775-018-1553-9. Epub 2018 Mar 23. |
| GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA. |
Albert-Gascó H, Ma S, Ros-Bernal F, Sánchez-Pérez AM, Gundlach AL, Olucha-Bordonau FE.
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| Front Neuroanat. 2018 Jan 17;11:133. doi: 10.3389/fnana.2017.00133. eCollection 2017. |
| Bioactive potential of silica coatings and its effect on the adhesion of proteins to titanium implants. |
Romero-Gavilan F, Araújo-Gomes N, Sánchez-Pérez AM, García-Arnáez I, Elortza F, Azkargorta M, de Llano JJM, Carda C, Gurruchaga M, Suay J, Goñi I.
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| Colloids Surf B Biointerfaces. 2018 Feb 1;162:316-325. doi: 10.1016/j.colsurfb.2017.11.072. Epub 2017 Dec 22. |
| Proteomic analysis of silica hybrid sol-gel coatings: a potential tool for predicting the biocompatibility of implants in vivo. |
Romero-Gavilan F, Sánchez-Pérez AM, Araújo-Gomes N, Azkargorta M, Iloro I, Elortza F, Gurruchaga M, Goñi I, Suay J.
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| Biofouling. 2017 Sep;33(8):676-689. doi: 10.1080/08927014.2017.1356289. |
| Characterization of serum proteins attached to distinct sol-gel hybrid surfaces. |
Araújo-Gomes N, Romero-Gavilán F, Sánchez-Pérez AM, Gurruchaga M, Azkargorta M, Elortza F, Martinez-Ibañez M, Iloro I, Suay J, Goñi I.
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| J Biomed Mater Res B Appl Biomater. 2018 May;106(4):1477-1485. doi: 10.1002/jbm.b.33954. Epub 2017 Jul 4. |
| The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation. |
Sánchez-Sarasúa S, Moustafa S, García-Avilés Á, López-Climent MF, Gómez-Cadenas A, Olucha-Bordonau FE, Sánchez-Pérez AM.
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| Nutr Metab (Lond). 2016 Oct 26;13:73. doi: 10.1186/s12986-016-0137-3. eCollection 2016. |
| Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory. |
Albert-Gascó H, García-Avilés Á, Moustafa S, Sánchez-Sarasua S, Gundlach AL, Olucha-Bordonau FE, Sánchez-Pérez AM.
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| Brain Struct Funct. 2017 Jan;222(1):449-463. doi: 10.1007/s00429-016-1227-8. Epub 2016 May 5. |
| Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala. |
Santos FN, Pereira CW, Sánchez-Pérez AM, Otero-García M, Ma S, Gundlach AL, Olucha-Bordonau FE.
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| Front Neuroanat. 2016 Apr 7;10:36. doi: 10.3389/fnana.2016.00036. eCollection 2016. |
| Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area. |
García-Avilés Á, Albert-Gascó H, Arnal-Vicente I, Elhajj E, Sanjuan-Arias J, Sanchez-Perez AM, Olucha-Bordonau F.
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| Front Neuroanat. 2015 Mar 23;9:33. doi: 10.3389/fnana.2015.00033. eCollection 2015. |
| Abscisic Acid: a versatile phytohormone in plant signaling and beyond. |
Gomez-Cadenas A, Vives V, Zandalinas SI, Manzi M, Sanchez-Perez AM, Perez-Clemente RM, Arbona V.
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| Curr Protein Pept Sci. 2015;16(5):413-34. Review. |
| Septal projections to nucleus incertus in the rat: bidirectional pathways for modulation of hippocampal function. |
Sánchez-Pérez AM, Arnal-Vicente I, Santos FN, Pereira CW, ElMlili N, Sanjuan J, Ma S, Gundlach AL, Olucha-Bordonau FE.
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| J Comp Neurol. 2015 Mar 1;523(4):565-88. doi: 10.1002/cne.23687. Epub 2014 Dec 19. |
| Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear. |
Pereira CW, Santos FN, Sánchez-Pérez AM, Otero-García M, Marchioro M, Ma S, Gundlach AL, Olucha-Bordonau FE.
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| Behav Brain Res. 2013 Jun 15;247:201-10. doi: 10.1016/j.bbr.2013.03.025. Epub 2013 Mar 26. |
| Parkinson's disease and autophagy. |
Sánchez-Pérez AM, Claramonte-Clausell B, Sánchez-Andrés JV, Herrero MT.
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| Parkinsons Dis. 2012;2012:429524. doi: 10.1155/2012/429524. Epub 2012 Oct 17. |
Sánchez-Pérez AM, García-Avilés Á, Albert Gascó H, Sanjuán J, Olucha-Bordonau FE.
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| Rev Neurol. 2012 Oct 16;55(8):499-506. Review. Spanish. |
| Distribution and targets of the relaxin-3 innervation of the septal area in the rat. |
Olucha-Bordonau FE, Otero-García M, Sánchez-Pérez AM, Núñez A, Ma S, Gundlach AL.
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| J Comp Neurol. 2012 Jun 15;520(9):1903-39. doi: 10.1002/cne.23018. |
| Chronic exposure to ammonia alters basal and NMDA-induced phosphorylation of NMDA receptor-subunit NR1. |
Sánchez-Pérez AM, Felipo V.
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| Neuroscience. 2006 Jul 21;140(4):1239-44. Epub 2006 May 4. |
| Modulation of NMDA receptors by AKT kinase. |
Sánchez-Pérez AM, Llansola M, Felipo V.
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| Neurochem Int. 2006 Sep;49(4):351-8. Epub 2006 Apr 18. |
| Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death. |
Giordano G, Sánchez-Pérez AM, Montoliu C, Berezney R, Malyavantham K, Costa LG, Calvete JJ, Felipo V.
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| J Neurochem. 2005 Aug;94(3):808-18. Epub 2005 Jul 5. |
| Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. |
Sánchez-Pérez AM, Felipo V.
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| Neurochem Int. 2005 Jul;47(1-2):84-91. |
| Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture. |
Giordano G, Sanchez-Perez AM, Burgal M, Montoliu C, Costa LG, Felipo V.
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| J Neurochem. 2005 Jan;92(1):143-57. |
| Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture. |
Llansola M, Sánchez-Pérez AM, Montoliu C, Felipo V.
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| J Neurochem. 2004 Nov;91(3):591-9. |
| Trialkylglycines: a new family of compounds with in vivo neuroprotective activity. |
Sánchez-Pérez AM, Montoliu C, Felipo V.
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| CNS Drug Rev. 2003 Fall;9(3):263-74. Review. |
| Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. |
Kosenko E, Llansola M, Montoliu C, Monfort P, Rodrigo R, Hernandez-Viadel M, Erceg S, Sánchez-Perez AM, Felipo V.
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| Neurochem Int. 2003 Sep-Oct;43(4-5):493-9. Review. |
| Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon. |
Hodge CW, Raber J, McMahon T, Walter H, Sanchez-Perez AM, Olive MF, Mehmert K, Morrow AL, Messing RO.
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| J Clin Invest. 2002 Oct;110(7):1003-10. |
| Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior. |
Ueno S, Harris RA, Messing RO, Sanchez-Perez AM, Hodge CW, McMahon T, Wang D, Mehmert KK, Kelley SP, Haywood A, Olive MF, Buck KJ, Hood HM, Blednov Y, Findlay G, Mascia MP.
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| Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):76S-81S. Review. |
| Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. |
Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS.
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| Neuron. 1999 Nov;24(3):659-72. |
| Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. |
Hodge CW, Mehmert KK, Kelley SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM, Messing RO.
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| Nat Neurosci. 1999 Nov;2(11):997-1002. |
| Cellular transcription factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognized by the viral E2 protein. |
Lewis H, Webster K, Sanchez-Perez AM, Gaston K.
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| J Gen Virol. 1999 Aug;80 ( Pt 8):2087-96. |
| Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis. |
Sanchez-Perez AM, Soriano S, Clarke AR, Gaston K.
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| J Gen Virol. 1997 Nov;78 ( Pt 11):3009-18. |
Vicente Herranz Pérez
| Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. |
Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT.
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| Mol Metab. 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. Epub 2018 Aug 21. |
| Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain. |
Fujikake K, Sawada M, Hikita T, Seto Y, Kaneko N, Herranz-Pérez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, García-Verdugo JM, Hattori M, Sobue K, Sawamoto K.
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| J Neurosci. 2018 May 9;38(19):4598-4609. doi: 10.1523/JNEUROSCI.1960-17.2018. Epub 2018 Apr 16. |
| Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury. |
Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.
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| Cell Stem Cell. 2018 Jan 4;22(1):128-137.e9. doi: 10.1016/j.stem.2017.11.005. Epub 2017 Dec 21. |
| Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells. |
Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM.
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| Stem Cell Reports. 2017 Jul 11;9(1):203-216. doi: 10.1016/j.stemcr.2017.05.024. Epub 2017 Jun 22. |
| Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes. |
Bruel AL, Franco B, Duffourd Y, Thevenon J, Jego L, Lopez E, Deleuze JF, Doummar D, Giles RH, Johnson CA, Huynen MA, Chevrier V, Burglen L, Morleo M, Desguerres I, Pierquin G, Doray B, Gilbert-Dussardier B, Reversade B, Steichen-Gersdorf E, Baumann C, Panigrahi I, Fargeot-Espaliat A, Dieux A, David A, Goldenberg A, Bongers E, Gaillard D, Argente J, Aral B, Gigot N, St-Onge J, Birnbaum D, Phadke SR, Cormier-Daire V, Eguether T, Pazour GJ, Herranz-Pérez V, Goldstein JS, Pasquier L, Loget P, Saunier S, Mégarbané A, Rosnet O, Leroux MR, Wallingford JB, Blacque OE, Nachury MV, Attie-Bitach T, Rivière JB, Faivre L, Thauvin-Robinet C.
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| J Med Genet. 2017 Jun;54(6):371-380. doi: 10.1136/jmedgenet-2016-104436. Epub 2017 Mar 13. Review. |
| Netrin-1 receptor antibodies in thymoma-associated neuromyotonia with myasthenia gravis. |
Torres-Vega E, Mancheño N, Cebrián-Silla A, Herranz-Pérez V, Chumillas MJ, Moris G, Joubert B, Honnorat J, Sevilla T, Vílchez JJ, Dalmau J, Graus F, García-Verdugo JM, Bataller L.
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| Neurology. 2017 Mar 28;88(13):1235-1242. doi: 10.1212/WNL.0000000000003778. Epub 2017 Mar 1. |
| An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling. |
Nager AR, Goldstein JS, Herranz-Pérez V, Portran D, Ye F, Garcia-Verdugo JM, Nachury MV.
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| Cell. 2017 Jan 12;168(1-2):252-263.e14. doi: 10.1016/j.cell.2016.11.036. Epub 2016 Dec 22. |
| Characterization of multiciliated ependymal cells that emerge in the neurogenic niche of the aged zebrafish brain. |
Ogino T, Sawada M, Takase H, Nakai C, Herranz-Pérez V, Cebrián-Silla A, Kaneko N, García-Verdugo JM, Sawamoto K.
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| J Comp Neurol. 2016 Oct 15;524(15):2982-92. doi: 10.1002/cne.24001. Epub 2016 Apr 4. |
| Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease. |
Bonet-Costa V, Herranz-Pérez V, Blanco-Gandía M, Mas-Bargues C, Inglés M, Garcia-Tarraga P, Rodriguez-Arias M, Miñarro J, Borras C, Garcia-Verdugo JM, Viña J.
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| J Alzheimers Dis. 2016;51(3):701-11. doi: 10.3233/JAD-151020. |
| The aged brain: genesis and fate of residual progenitor cells in the subventricular zone. |
Capilla-Gonzalez V, Herranz-Pérez V, García-Verdugo JM.
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| Front Cell Neurosci. 2015 Sep 24;9:365. doi: 10.3389/fncel.2015.00365. eCollection 2015. Review. |
| Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium. |
Ohata S, Herranz-Pérez V, Nakatani J, Boletta A, García-Verdugo JM, Álvarez-Buylla A.
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| J Neurosci. 2015 Aug 5;35(31):11153-68. doi: 10.1523/JNEUROSCI.0686-15.2015. |
| Neurotoxic effects of ochratoxin A on the subventricular zone of adult mouse brain. |
Paradells S, Rocamonde B, Llinares C, Herranz-Pérez V, Jimenez M, Garcia-Verdugo JM, Zipancic I, Soria JM, Garcia-Esparza MA.
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| J Appl Toxicol. 2015 Jul;35(7):737-51. doi: 10.1002/jat.3061. Epub 2014 Sep 25. |
| Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus. |
Ohata S, Nakatani J, Herranz-Pérez V, Cheng J, Belinson H, Inubushi T, Snider WD, García-Verdugo JM, Wynshaw-Boris A, Alvarez-Buylla A.
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| Neuron. 2014 Aug 6;83(3):558-71. doi: 10.1016/j.neuron.2014.06.022. Epub 2014 Jul 18. |
| The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. |
Thauvin-Robinet C, Lee JS, Lopez E, Herranz-Pérez V, Shida T, Franco B, Jego L, Ye F, Pasquier L, Loget P, Gigot N, Aral B, Lopes CA, St-Onge J, Bruel AL, Thevenon J, González-Granero S, Alby C, Munnich A, Vekemans M, Huet F, Fry AM, Saunier S, Rivière JB, Attié-Bitach T, Garcia-Verdugo JM, Faivre L, Mégarbané A, Nachury MV.
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| Nat Genet. 2014 Aug;46(8):905-11. doi: 10.1038/ng.3031. Epub 2014 Jul 6. |
| Long-term hydrocephalus alters the cytoarchitecture of the adult subventricular zone. |
Campos-Ordoñez T, Herranz-Pérez V, Chaichana KL, Rincon-Torroella J, Rigamonti D, García-Verdugo JM, Quiñones-Hinojosa A, Gonzalez-Perez O.
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| Exp Neurol. 2014 Nov;261:236-44. doi: 10.1016/j.expneurol.2014.05.011. Epub 2014 May 21. |
| Orthogonal functionalisation of upconverting NaYF4 nanocrystals. |
Voliani V, González-Béjar M, Herranz-Pérez V, Duran-Moreno M, Signore G, Garcia-Verdugo JM, Pérez-Prieto J.
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| Chemistry. 2013 Sep 27;19(40):13538-46. doi: 10.1002/chem.201301353. Epub 2013 Aug 13. |
| Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. |
Herranz-Pérez V, Olucha-Bordonau FE, Morante-Redolat JM, Pérez-Tur J.
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| Brain Res. 2010 Jan 11;1307:177-94. doi: 10.1016/j.brainres.2009.10.013. Epub 2009 Oct 13. |
| The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. |
Sirerol-Piquer MS, Ayerdi-Izquierdo A, Morante-Redolat JM, Herranz-Pérez V, Favell K, Barker PA, Pérez-Tur J.
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| Hum Mol Genet. 2006 Dec 1;15(23):3436-45. Epub 2006 Oct 26. |
| LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain. |
Simón-Sánchez J, Herranz-Pérez V, Olucha-Bordonau F, Pérez-Tur J.
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| Eur J Neurosci. 2006 Feb;23(3):659-66. |
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