Los Clinical Trials de Kite-Gilead sobre los CAR-T de las CD19

En ASCO 2018  se presentó un nuevo ensayo clínico de Kite-Gilead sobre las CAR-T en CD19: ZUMA-7:A phase 3 randomized trial of axicabtagene ciloleucel (Axi-Cel) versus standard-of-care (SOC) therapy in patients with relapsed/refractory diffuse large B cell lymphoma (R/R DLBCL).

Cacharreando en Clinicaltrials.gov hemos encontrado los ensayos clínicos que han puesto en marcha la empresa desde el ZUMA-1 hasta el presentado en ASCO. Abajo algunas de sus características.
En ZUMA-7  participa la Universidad de Salamanca (Dolores Caballero Barrigón)

NCT Number	Title	Acronym	Age	Phases	Enrollment	Start Date	Primary     Completion Date	URL
NCT02348216	A Phase 1-2 Multi-Center Study Evaluating Axicabtagene Ciloleucel in Subjects With Refractory Aggressive Non-Hodgkin Lymphoma (ZUMA-1)	ZUMA-1	18 Years and older  (Adult, Older Adult)	Phase 1|Phase 2	200	January 2015	August 2018	https://ClinicalTrials.gov/show/NCT02348216
NCT02601313	A Phase 2 Multicenter Study Evaluating Subjects With Relapsed/Refractory Mantle Cell Lymphoma	ZUMA-2	18 Years and older  (Adult, Older Adult)	Phase 2	80	November 2015	December 2019	https://ClinicalTrials.gov/show/NCT02601313
NCT02614066	A Study Evaluating KTE-C19 in Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r ALL) (ZUMA-3)	ZUMA-3	18 Years and older  (Adult, Older Adult)	Phase 1|Phase 2	75	November 2015	March 2019	https://ClinicalTrials.gov/show/NCT02614066
NCT02625480	A Multi-Center Study Evaluating KTE-C19 in Pediatric and Adolescent Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia	ZUMA-4	2 Years to 21 Years   (Child, Adult)	Phase 1|Phase 2	75	December 2015	June 2019	https://ClinicalTrials.gov/show/NCT02625480
NCT03105336	A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects With Relapsed/Refractory Indolent Non-Hodgkin Lymphoma	ZUMA-5	18 Years and older   (Adult, Older Adult)	Phase 2	50	May 10, 2017	December 2018	https://ClinicalTrials.gov/show/NCT03105336
NCT02926833	A Study Evaluating KTE-C19 in Combination With Atezolizumab in Subjects With Refractory Diffuse Large B-Cell Lymphoma (DLBCL)	ZUMA-6	18 Years and older   (Adult, Older Adult)	Phase 1|Phase 2	31	September 2016	June 2018	https://ClinicalTrials.gov/show/NCT02926833
NCT03391466	A Study Evaluating the Efficacy of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma	ZUMA-7	18 Years and older   (Adult, Older Adult)	Phase 3	350	December 14, 2017	January 15, 2022	https://ClinicalTrials.gov/show/NCT03391466
NCT03153462	Axicabtagene Ciloleucel Expanded Access Study	ZUMA-9	18 Years and older   (Adult, Older Adult)		null	null	null	https://ClinicalTrials.gov/show/NCT03153462

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